Facilitator Models of Weak Binding in Protein-Protein Interactions
نویسندگان
چکیده
منابع مشابه
A DNA-assisted binding assay for weak protein-protein interactions.
We describe a new method used for quantitating weak interactions between proteins in which the weak interaction is "assisted" by a known DNA-DNA interaction. Oligonucleotides, which are conjugated to proteins of interest, contain short complementary DNA sequences that provide additional binding energy for protein-protein interactions. A stretch of unpaired bases links the protein to the hybridi...
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Models for Protein Interactions
Recent advances in high-throughput experimental techniques have given us a wealth of protein interaction data, rich in quantity and variety. While the quantity and variety of data present special challenges for modeling, they also present unique opportunities for gaining insight into the proteome by allowing us to leverage multiple perspectives. We present TOPROC (TOpology of PROtein Complexes)...
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ژورنال
عنوان ژورنال: Biophysical Journal
سال: 2017
ISSN: 0006-3495
DOI: 10.1016/j.bpj.2016.11.1724